pemphigus

Pemphigus is an autoimmune disorder. If you have it, your immune system attacks healthy cells in your skin and mouth, causing blisters and sores. No one knows the cause. Pemphigus does not spread from person to person. It does not appear to be inherited. But some people's genes put them more at risk for pemphigus.

Pemphigoid is also an autoimmune skin disease. It leads to deep blisters that do not break easily. Pemphigoid is most common in older adults and may be fatal for older, sick patients.

Doctors diagnose pemphigus with a physical exam, a biopsy, and blood tests. The treatment of pemphigus and pemphigoid is the same: one or more medicines to control symptoms. These may include:

• Steroids, which reduce inflammation
• Drugs that suppress the immune system response
• Antibiotics to treat associated infections

NIH: National Institute of Arthritis and Musculoskeletal and Skin Diseases

Blisters are fluid-filled sacs on the outer layer of your skin. They form because of rubbing, heat, or diseases of the skin. They are most common on your hands and feet.

Other names for blisters are vesicles (usually for smaller blisters) and bulla (for larger blisters).

Blisters often happen when there is friction - rubbing or pressure - on one spot. For example, if your shoes don't fit quite right and they keep rubbing part of your foot. Or if you don't wear gloves when you rake leaves and the handle keeps rubbing against your hand. Other causes of blisters include:

• Burns
• Sunburn
• Frostbite
• Eczema
• Allergic reactions
• Poison ivy, oak, and sumac
• Autoimmune diseases such as pemphigus
• Epidermolysis bullosa, an illness that causes the skin to be fragile
• Viral infections such as varicella zoster (which causes chickenpox and shingles) and herpes simplex (which causes cold sores)
• Skin infections including impetigo

Blisters will usually heal on their own. The skin over the blister helps keep out infections. You can put a bandage on the blister to keep it clean. Make sure that there is no more rubbing or friction on the blister.

You should contact your health care provider if:

• The blister looks infected - if it is draining pus, or the area around the blister is red, swollen, warm, or very painful
• You have a fever
• You have several blisters, especially if you cannot figure out what is causing them
• You have health problems such as circulation problems or diabetes

Normally you don't want to drain a blister, because of the risk of infection. But if a blister is large, painful, or looks like it will pop on its own, you can drain the fluid.

There are some things you can do to prevent friction blisters:

• Make sure that your shoes fit properly
• Always wear socks with your shoes, and make sure that the socks fit well. You may want to wear socks that are acrylic or nylon, so they keep moisture away from your feet.
• Wear gloves or protective gear on your hands when you use any tools or sports equipment that cause friction.

Your mouth is one of the most important parts of your body. It has many different functions. It allows you to:

• Take in food and drink
• Breathe in air
• Start digestion, with your teeth chewing the food you eat and your salivary glands releasing saliva to help break down the food
• Speak and sing
• Show emotion, by smiling or pouting

Any problem that affects your mouth can make it hard to eat, drink, or even smile. Some common mouth problems include:

• Cold sores - painful sores on the lips and around the mouth, caused by a virus
• Canker sores - painful sores in the mouth, caused by bacteria or viruses
• Thrush - a yeast infection that causes white patches in your mouth
• Leukoplakia - white patches of excess cell growth on the cheeks, gums or tongue, common in smokers
• Dry mouth - a lack of enough saliva, caused by some medicines and certain diseases
• Gum or tooth problems
• Bad breath

Treatment for mouth disorders varies, depending on the problem. If a mouth problem is caused by some other disease, treating that disease can help. It is also important to keep your mouth clean and healthy by brushing, flossing, and not using tobacco.