carcinomatosis

Skin cancer is the most common form of cancer in the United States. The two most common types are basal cell cancer and squamous cell cancer. They usually form on the head, face, neck, hands, and arms. Another type of skin cancer, melanoma, is more dangerous but less common.

Anyone can get skin cancer, but it is more common in people who :

• Spend a lot of time in the sun or have been sunburned
• Have light-colored skin, hair and eyes
• Have a family member with skin cancer
• Are over age 50

You should have your doctor check any suspicious skin markings and any changes in the way your skin looks. Treatment is more likely to work well when cancer is found early. If not treated, some types of skin cancer cells can spread to other tissues and organs. Treatments include surgery, radiation therapy, chemotherapy, photodynamic therapy (PDT), and biologic therapy. PDT uses a drug and a type of laser light to kill cancer cells. Biologic therapy boosts your body's own ability to fight cancer.

NIH: National Cancer Institute

Cancer begins in your cells, which are the building blocks of your body. Normally, your body forms new cells as you need them, replacing old cells that die. Sometimes this process goes wrong. New cells grow even when you don't need them, and old cells don't die when they should. These extra cells can form a mass called a tumor. Tumors can be benign or malignant. Benign tumors aren't cancer while malignant ones are. Cells from malignant tumors can invade nearby tissues. They can also break away and spread to other parts of the body.

Cancer is not just one disease but many diseases. There are more than 100 different types of cancer. Most cancers are named for where they start. For example, lung cancer starts in the lung, and breast cancer starts in the breast. The spread of cancer from one part of the body to another is called metastasis. Symptoms and treatment depend on the cancer type and how advanced it is. Most treatment plans may include surgery, radiation and/or chemotherapy. Some may involve hormone therapy, immunotherapy or other types of biologic therapy, or stem cell transplantation.

NIH: National Cancer Institute

Your liver is the largest organ inside your body. It helps your body digest food, store energy, and remove poisons. Primary liver cancer starts in the liver. Metastatic liver cancer starts somewhere else and spreads to your liver.

Risk factors for primary liver cancer include :

• Having hepatitis B or C
• Heavy alcohol use
• Having cirrhosis, or scarring of the liver
• Having hemochromatosis, an iron storage disease
• Obesity and diabetes

Symptoms can include a lump or pain on the right side of your abdomen and yellowing of the skin. However, you may not have symptoms until the cancer is advanced. This makes it harder to treat. Doctors use tests that examine the liver and the blood to diagnose liver cancer. Treatment options include surgery, radiation, chemotherapy, or liver transplantation.

NIH: National Cancer Institute

Lung cancer is cancer that forms in tissues of the lung, usually in the cells that line the air passages. It is the leading cause of cancer death in both men and women.

There are two main types: small cell lung cancer and non-small cell lung cancer. These two types grow differently and are treated differently. Non-small cell lung cancer is the more common type.

Anyone can develop lung cancer, but certain factors raise your risk of getting it:

• Smoking. This is the most important risk factor for lung cancer. Tobacco smoking causes about 9 out of 10 cases of lung cancer in men and about 8 out of 10 cases of lung cancer in women. The more years you smoke and the more cigarettes you smoke each day, the more your risk goes up. Your risk is also greater if you smoke a lot and drink alcohol every day or take beta carotene supplements. If you have quit smoking, your risk will be lower than if you had kept smoking. But you will still have a higher risk than people who never smoked.
• Secondhand smoke, which is the combination of the smoke that comes from a cigarette and the smoke breathed out by a smoker. When you breathe in secondhand smoke, you are exposed to the same cancer-causing agents as smokers, although in smaller amounts.
• A family history of lung cancer.
• Being exposed to asbestos, arsenic, chromium, beryllium, nickel, soot, or tar in the workplace.
• Being exposed to radiation, for example from:
  • Radiation therapy to the breast or chest
  • Radon in the home or workplace
  • Certain imaging tests such as CT scans
• HIV infection. Your risk is higher if you have HIV. However, smoking rates are higher in people who have HIV, so it's not clear whether the increased risk is from the HIV infection or from smoking.
• Air pollution. Studies show that living in areas with higher levels of air pollution increases your risk of lung cancer.

Lung cancer may not cause any signs or symptoms until the cancer is advanced. Sometimes the cancer is found during a chest x-ray done for another condition.

The symptoms of lung cancer may include:

• Chest pain or discomfort
• A cough that doesn't go away or gets worse over time
• Coughing up blood
• Trouble breathing
• Wheezing
• Hoarseness
• Loss of appetite
• Weight loss for no known reason
• Feeling very tired
• Trouble swallowing
• Swelling in the face and/or veins in the neck

To find out if you have lung cancer, your health care provider:

• Will take your medical history, which includes asking about your symptoms
• Will ask about your family history
• Will do a physical exam
• May order certain imaging tests, such as a chest x-ray or chest CT scan
• May order lab tests, including tests of your blood and sputum
• May do a procedure to take a biopsy of the lung

If you do have lung cancer, your provider will do other tests to find out if it has spread through the lungs, lymph nodes, and the rest of the body. This is called staging. Knowing the type and stage of lung cancer you have helps your provider decide what kind of treatment you need.

If you have small-cell lung cancer, your provider may also do genetic testing to look for certain gene changes (variants) in your cancer cells. The results of the testing may help guide treatment.

For most patients with lung cancer, current treatments do not cure the cancer.

Your treatment will depend on which type of lung cancer you have, how far it has spread, your overall health, and other factors. You may get more than one type of treatment.

The treatments for small cell lung cancer may include:

• Surgery.
• Chemotherapy.
• Radiation therapy.
• Immunotherapy.
• Laser therapy, which uses a laser beam to kill cancer cells.
• Endoscopic stent placement. An endoscope is a thin, tube-like instrument used to look at tissues inside the body. It may be used to put in a device called a stent. The stent helps to open an airway that has been blocked by abnormal tissue.

The treatments for non-small cell lung cancer may include:

• Surgery.
• Radiation therapy.
• Chemotherapy.
• Targeted therapy, which uses drugs or other substances that attack specific cancer cells with less harm to normal cells.
• Immunotherapy.
• Laser therapy.
• Photodynamic therapy (PDT), which uses a medicine and a certain type of laser light to kill cancer cells.
• Cryosurgery, which uses an instrument to freeze and destroy abnormal tissue.
• Electrocautery, a treatment that uses a probe or needle heated by an electric current to destroy abnormal tissue.

Avoiding the risk factors may help prevent lung cancer. For example, you can:

• Quit smoking. And if you don't smoke, don't start.
• Lower your exposure to hazardous substances at work.
• Lower your exposure to radon. Radon tests can show whether your home has high levels of radon. You can buy a test kit yourself or hire a professional to do the test.

NIH: National Cancer Institute

The pancreas is a gland behind your stomach and in front of your spine. It produces the juices that help break down food and the hormones that help control blood sugar levels. Pancreatic cancer usually begins in the cells that produce the juices. Some risk factors for developing pancreatic cancer include:

• Smoking
• Long-term diabetes
• Chronic pancreatitis
• Certain hereditary disorders

Pancreatic cancer is hard to catch early. It doesn't cause symptoms right away. When you do get symptoms, they are often vague or you may not notice them. They include yellowing of the skin and eyes, pain in the abdomen and back, weight loss and fatigue. Also, because the pancreas is hidden behind other organs, health care providers cannot see or feel the tumors during routine exams. Doctors use a physical exam, blood tests, imaging tests, and a biopsy to diagnose it.

Because it is often found late and it spreads quickly, pancreatic cancer can be hard to treat. Possible treatments include surgery, radiation, chemotherapy, and targeted therapy. Targeted therapy uses drugs or other substances that attack specific cancer cells with less harm to normal cells.

NIH: National Cancer Institute

Breast cancer is a cancer that starts in breast tissue. It happens when cells in the breast change and grow out of control. The cells usually form a tumor.

Sometimes the cancer does not spread any further. This is called "in situ." If the cancer spreads outside the breast, the cancer is called "invasive." It may just spread to nearby tissues and lymph nodes. Or the cancer may metastasize (spread to other parts of the body) through the lymph system or the blood.

Breast cancer is the second most common type of cancer in women in the United States. Rarely, it can also affect men.

There are different types of breast cancer. The types are based on which breast cells turn into cancer. The types include:

• Ductal carcinoma, which begins in the cells of the ducts. This is the most common type.
• Lobular carcinoma, which begins in the lobules. It is more often found in both breasts than other types of breast cancer.
• Inflammatory breast cancer, in which cancer cells block lymph vessels in the skin of the breast. The breast becomes warm, red, and swollen. This is a rare type.
• Paget's disease of the breast, which is a cancer involving the skin of the nipple. It usually also affects the darker skin around the nipple. It is also rare.

Breast cancer happens when there are changes in the genetic material (DNA). Often, the exact cause of these genetic changes is unknown.

But sometimes these genetic changes are inherited, meaning that you are born with them. Breast cancer that is caused by inherited genetic changes is called hereditary breast cancer.

There are also certain genetic changes that can raise your risk of breast cancer, including changes in the BRCA1 and BRCA2 genes. These two changes also raise your risk of ovarian and other cancers.

Besides genetics, your lifestyle and the environment can affect your risk of breast cancer.

The factors that raise your risk of breast cancer include:

• Older age
• History of breast cancer or benign (noncancer) breast disease
• Inherited risk of breast cancer, including having BRCA1 and BRCA2 gene changes
• Dense breast tissue
• A reproductive history that leads to more exposure to the estrogen hormone, including
  • Menstruating at an early age
  • Being at an older age when you first gave birth or never having given birth
  • Starting menopause at a later age
• Taking hormone therapy for symptoms of menopause
• Radiation therapy to the breast or chest
• Obesity
• Drinking alcohol

The signs and symptoms of breast cancer include:

• A new lump or thickening in or near the breast or in the armpit.
• A change in the size or shape of the breast.
• A dimple or puckering in the skin of the breast. It may look like the skin of an orange.
• A nipple turned inward into the breast.
• Nipple discharge other than breast milk. The discharge might happen suddenly, be bloody, or happen in only one breast.
• Scaly, red, or swollen skin in the nipple area or the breast
• Pain in any area of the breast.

Your health care provider may use many tools to diagnose breast cancer and figure out which type you have:

• A physical exam, including a clinical breast exam (CBE). This involves checking for any lumps or anything else that seems unusual with the breasts and armpits.
• A medical history.
• Imaging tests, such as a mammogram, an ultrasound, or an MRI.
• Breast biopsy.
• Blood chemistry tests, which measure different substances in the blood, including electrolytes, fats, proteins, glucose (sugar), and enzymes. Some of the specific blood chemistry tests include a basic metabolic panel (BMP), a comprehensive metabolic panel (CMP), and an electrolyte panel.

If these tests show that you have breast cancer, you will have tests that study the cancer cells. These tests help your provider decide which treatment would be best for you. The tests may include:

• Genetic tests for genetic changes such as in the BRCA and TP53 genes.
• HER2 test. HER2 is a protein involved with cell growth. It is on the outside of all breast cells. If your breast cancer cells have more HER2 than normal, they can grow more quickly and spread to other parts of the body.
• An estrogen and progesterone receptor test. This test measures the amount of estrogen and progesterone (hormones) receptors in cancer tissue. If there are more receptors than normal, the cancer is called estrogen and/or progesterone receptor positive. This type of breast cancer may grow more quickly.

Another step is staging the cancer. Staging involves doing tests to find out whether the cancer has spread within the breast or to other parts of the body. The tests may include other diagnostic imaging tests and a sentinel lymph node biopsy. This biopsy is done to see whether the cancer has spread to the lymph nodes.

Treatments for breast cancer include:

• Surgery such as
  • A mastectomy, which removes the whole breast
  • A lumpectomy to remove the cancer and some normal tissue around it, but not the breast itself
• Radiation therapy
• Chemotherapy
• Hormone therapy, which blocks cancer cells from getting the hormones they need to grow
• Targeted therapy, which uses drugs or other substances that attack specific cancer cells with less harm to normal cells
• Immunotherapy

You may be able to help prevent breast cancer by making healthy lifestyle changes such as:

• Staying at a healthy weight
• Limiting alcohol use
• Getting enough exercisee
• Limiting your exposure to estrogen by
  • Breastfeeding your babies if you can
  • Limiting hormone therapy

If you are at high risk, your health care provider may suggest that you take certain medicines to lower the risk. Some women at very high risk may decide to get a mastectomy (of their healthy breasts) to prevent breast cancer.

It's also important to get regular mammograms. They may be able to identify breast cancer in the early stages, when it is easier to treat.

NIH: National Cancer Institute

Your adrenal, or suprarenal, glands are located on the top of each kidney. These glands produce hormones that you can't live without, including sex hormones and cortisol, which helps you respond to stress and has many other functions.

A number of disorders can affect the adrenal glands, including tumors. Tumors can be either benign or malignant. Benign tumors aren't cancer. Malignant ones are. Most adrenal gland tumors are benign. They usually do not cause symptoms and may not require treatment. Malignant adrenal gland cancers are uncommon.

Types of tumors include:

• Adrenocortical carcinoma - cancer in the outer part of the gland
• Neuroblastoma, a type of childhood cancer
• Pheochromocytoma - a rare tumor that is usually benign

Symptoms depend on the type of cancer you have. Treatments may include surgery, chemotherapy, or radiation therapy.

The thymus is a small organ in your upper chest, under your breastbone. Before birth and during childhood, the thymus helps the body make a type of white blood cell. These cells help protect you from infections.

Cancer of the thymus is rare. You are more likely to get it if you have other diseases such as myasthenia gravis, lupus or rheumatoid arthritis. Sometimes there are no symptoms. Other times, thymus cancer can cause:

• A cough that doesn't go away
• Chest pain
• Trouble breathing

Doctors use a physical exam, imaging tests, and a biopsy to diagnose thymus cancer. The most common treatment is surgery to remove the tumor. Other options include radiation therapy, chemotherapy, and hormone therapy.

NIH: National Cancer Institute

Head and neck cancer is the name for cancers that develop in the mouth, nose and sinuses, salivary glands, and throat and voice box (larynx). Most head and neck cancers are squamous cell cancers. They begin in the moist tissues that line the head and neck. The cancer cells may spread into deeper tissue as the cancer grows.

There are other cancers that develop in the head and neck, such as brain cancer, eye cancer, and esophageal cancer. But they are usually not considered to be head and neck cancers, because those types of cancer and their treatments are different.

Anyone can get head and neck cancer, but you are more likely to develop it if you:

• Use tobacco or drink lots of alcohol. Your risk of developing head and neck cancer is even higher if you do both.
• Are male.
• Are over age 50.
• Have a history of head or neck cancer.
• Have HPV (for cancers in the tonsils and base of the tongue).
• Are exposed to wood dusts or certain other toxic substances at work (for upper throat, nose, and sinus cancers).
• Have had radiation exposure to the head and neck (for salivary gland cancer).
• Have Epstein-Barr virus (EBV) infection (for upper throat and salivary gland cancers).
• Are Asian (for upper throat cancer).

The symptoms of head and neck cancer may include:

• A lump in the neck
• A sore in the mouth or the throat that does not heal and may be painful
• A sore throat that does not go away
• Trouble swallowing
• A change or hoarseness in the voice

Other possible symptoms can depend on the specific type of head and neck cancer.

Which exams and tests used to diagnose head and neck cancer can depend on the specific type of cancer. Possible exams and tests may include:

• A physical exam of the area that might have cancer.
• Blood and/or urine tests.
• An endoscopy.
• A biopsy or other procedure to collect cells from the area that might have cancer. The cells are viewed under a microscope to find out if they are abnormal.
• Imaging tests.

The treatment for head and neck cancer will depend on the specific type of cancer, the stage (how advanced the cancer is), your overall health, and other factors. The treatment options might include:

• Surgery
• Radiation therapy
• Chemotherapy
• Cancer immunotherapy
• Targeted therapy, which uses drugs or other substances that mainly attack specific cancer cells and cause less harm to normal cells

In some cases, you may need a combination of treatments. Sometimes surgery can affect how well you can chew, swallow, or talk. Rehabilitation, such as physical therapy, dietary counseling, and speech therapy, may help.

There are steps you can take to help prevent head and neck cancer:

• Not smoking
• Limiting alcohol use or not drinking at all
• Getting regular dental exams
• Talking to your provider about HPV vaccination

NIH: National Cancer Institute

You have two kidneys. They are fist-sized organs on either side of your backbone above your waist. The tubes inside filter and clean your blood, taking out waste products and making urine. Kidney cancer forms in the lining of tiny tubes inside your kidneys.

Kidney cancer becomes more likely as you age. Risk factors include smoking, having certain genetic conditions, and misusing pain medicines for a long time.

You may have no symptoms at first. They may appear as the cancer grows. See your health care provider if you notice:

• Blood in your urine
• A lump in your abdomen
• Weight loss for no reason
• Pain in your side that does not go away
• Loss of appetite

Tests to diagnose kidney cancer include blood, urine, and imaging tests. You may also have a biopsy.

Treatment depends on your age, your overall health and how advanced the cancer is. It might include surgery, chemotherapy, or radiation, biologic, or targeted therapies. Biologic therapy boosts your body's own ability to fight cancer. Targeted therapy uses drugs or other substances that attack specific cancer cells with less harm to normal cells.

NIH: National Cancer Institute