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Reye syndrome is a rare illness that can affect the blood, liver, and brain of someone who has recently had a viral infection. It always follows another illness. Although it mostly affects children and teens, anyone can get it. It can develop quickly and without warning. It is most common during flu season. Symptoms include:

• Nausea and vomiting
• Listlessness
• Personality change - such as irritability, combativeness or confusion
• Delirium
• Convulsions
• Loss of consciousness

If these symptoms occur soon after a viral illness, seek medical attention immediately. Reye syndrome can lead to a coma and brain death, so quick diagnosis and treatment are critical. Treatment focuses on preventing brain damage. There is no cure.

The cause of Reye syndrome is unknown. Studies have shown that taking aspirin increases the risk of getting it. Because of that, health care professionals now recommend other pain relievers for young patients.

NIH: National Institute of Neurological Disorders and Stroke

Chickenpox is an infection caused by the varicella-zoster virus. Most cases are in children under age 15, but older children and adults can get it. It spreads very easily from one person to another.

The classic symptom of chickenpox is an uncomfortable, itchy rash. The rash turns into fluid-filled blisters and eventually into scabs. It usually shows up on the face, chest, and back and then spreads to the rest of the body. Other symptoms include:

• Fever
• Headache
• Tiredness
• Loss of appetite

Chickenpox is usually mild and lasts 5 to 10 days. Calamine lotions and oatmeal baths can help with itching. Acetaminophen can treat the fever. Do not use aspirin for chickenpox; that combination can cause Reye syndrome.

Chickenpox can sometimes cause serious problems. Adults, babies, teenagers, pregnant women, and those with weak immune systems tend to get sicker from it. They may need to take antiviral medicines.

Once you catch chickenpox, the virus usually stays in your body. You probably will not get chickenpox again, but the virus can cause shingles in adults. A chickenpox vaccine can help prevent most cases of chickenpox, or make it less severe if you do get it.

Centers for Disease Control and Prevention

Fifth disease, also called erythema infectiosum, is a viral infection caused by parvovirus B19. This virus only infects people; it's not the same type of parvovirus that dogs and cats can get.

Fifth disease mostly affects children. It often causes a bright red rash on their cheeks (sometimes called a "slapped cheek" rash).

In the United States, parvovirus B19 infections are more common in late winter, spring, and early summer. There are usually minor outbreaks of fifth disease about every 3 to 4 years.

Parvovirus B19, which causes fifth disease, can spread from person to person:

• Through respiratory droplets, such as saliva (spit), sputum, or nasal mucus. The droplets can spread when:
  • Someone who has the virus coughs and sneezes
  • You touch an item that has the virus on it
• Through blood or blood products
• From a pregnant parent to the baby during pregnancy

You are most contagious early in your infection, when you usually only have a fever or cold-like symptoms. You are not likely to be contagious after you get later symptoms such as a rash and joint pain.

About 2 out of 10 people who get a B19 parvovirus infection will have no symptoms.

But most people will get the symptoms of fifth disease, which are usually mild and can include:

• Fever
• Headache
• Cough
• Sore throat
• Rashes
• Joint pain

The "slapped cheek" rash is more common in children. They usually get the rash a few days after they first have other symptoms. The rash can then spread to the arms, legs, chest, back, and buttocks.

Adults who get fifth disease might also have joint pain and swelling (called polyarthropathy syndrome).

Sometimes the infection can cause serious health complications affecting the nerves, joints, or blood system. This is more likely to happen if you are pregnant, have a blood disorder such as anemia, or a weakened immune system.

Because of these risks to you and some possible risks to your baby, contact your health care provider if you are pregnant and:

• You show signs of fifth disease (or a "slapped cheek" rash)
• You may have been exposed to someone who has the infection

There is no routine lab test to diagnose fifth disease. Providers can often diagnose fifth disease just by seeing the "slapped cheek" rash and rashes on the body.

There is testing to show whether or not you have protection (immunity) against the B19 parvovirus or if you have had a recent infection. This test is usually not needed, but your provider may order the test if you are pregnant or at higher risk for complications of the disease.

There is no specific treatment for fifth disease. It is usually mild and goes away on its own.

To feel better, get plenty of rest. Taking acetaminophen can help with the fever and pain. Do not give aspirin to children, because it may cause Reye syndrome. This is a rare, serious illness that can affect the brain and liver.

There is no vaccine to prevent fifth disease. But you can help protect yourself and others by:

• Washing your hands often with soap and water
• Covering your mouth and nose when you cough or sneeze
• Avoiding touching your eyes, nose, and mouth with unwashed hands
• Avoiding close contact with people who are sick
• Staying home when you are sick

Most people become immune to the virus after having it once.

Centers for Disease Control and Prevention

Infectious mononucleosis (mono) is a disease caused by viruses.The most common cause is the Epstein-Barr virus (EBV). Mono is contagious, which means it can spread from person to person. It is common among teenagers and young adults, especially college students.

Mono can be caused by many different viruses. But it is most often caused by the Epstein-Barr virus (EBV). EBV is found all over the world. Most people get an EBV infection at some point in their lives, but only some of them will get the symptoms of mono. EBV infections often happen during childhood or when someone is a young adult. EBV infections in children usually do not cause symptoms. And when they do, it's hard to tell the difference between the symptoms of mono and the symptoms of other common childhood illnesses such as the flu. Teens and young adults who get EBV are more likely to have symptoms that are typical of mono.

EBV and the other viruses that cause mono are usually spread through body fluids, especially saliva (spit). This means that you can get it through kissing. That's why mono is sometimes called "the kissing disease." But you can also get these viruses if you share food, drinks, forks, spoons, or lip balm with someone who has mono. Other less common ways of getting an infection are through blood transfusions, organ transplants, and blood and semen during sexual contact.

The symptoms of mono usually start four to six weeks after you get the infection. But they may start sooner in young children. The symptoms often develop slowly, and they may not all happen at the same time. They can include:

• Extreme fatigue
• Fever
• Sore throat
• Head and body aches
• Swollen lymph glands in your neck and armpits
• Rash
• Swollen liver, spleen, or both (these are less common symptoms)

Most people get better in two to four weeks. However, some people may feel fatigued for several more weeks. Occasionally, the symptoms can last for six months or longer.

Your healthcare provider may diagnose mono based on your symptoms and a physical exam. The exam will include checking to see if your lymph nodes, tonsils, liver, or spleen are swollen. In some cases, your provider might also order a mono test to confirm the diagnosis.

• Drinking plenty of fluids to avoid dehydration.
• Getting lots of rest.
• Taking over-the-counter medications for pain and fever. But don't give aspirin to children or teens because it may cause Reye syndrome. This syndrome is a rare, serious illness that can affect the brain and liver.

If you have severe symptoms, your provider may suggest additional treatment based on which organs in your body are affected by the mono.

Antibiotics don't treat viral infections, so they do not help with mono. Some people do get bacterial infections such as strep throat along with mono. In that case, you probably need antibiotics to treat the bacterial infection. But you should not take penicillin antibiotics like ampicillin or amoxicillin. Those antibiotics can cause a rash in people who have mono.

Mono can cause an enlarged spleen, which could rupture and cause a medical emergency. To try to protect the spleen, providers recommend avoiding intense exercise and contact sports until you fully recover (about a month).

There is no vaccine to protect against mono. To lower your chance of getting or spreading mono:

• Don't share food, drinks, forks, spoons, or lip balm with anyone, especially if you or the other person has mono.
• Don't kiss someone if you or the other person has mono.
• Wash your hands often with soap and water.

Centers for Disease Control and Prevention

Kawasaki disease is a rare illness that usually affects small children. Other names for the disease are Kawasaki syndrome and mucocutaneous lymph node syndrome. It is a type of vasculitis, which is inflammation of the blood vessels. Kawasaki disease is serious, but most children can fully recover if they are treated right away.

Kawasaki disease happens when the immune system injures the blood vessels by mistake. Researchers do not fully know why this happens. But when it does, the blood vessels become inflamed and can narrow or close off.

Genetics may play a role in Kawasaki disease. There may also be environmental factors, such as infections. It does not seem to be contagious. This means that it cannot be passed from one child to another.

Kawasaki disease usually affects children under the age of 5. But older children and adults can sometimes get it. It is more common in boys than girls. It can affect children of any race, but those with Asian or Pacific Islander descent are more likely to get it.

The symptoms of Kawasaki disease may include:

• High fever lasting at least five days
• A rash, often on the back, chest, and groin
• Swollen hands and feet
• Redness of the lips, lining of the mouth, tongue, palms of the hand, and soles of the feet
• Pink eye (conjunctivitis)
• Swollen lymph nodes in the neck

Contact your child's health care provider if your child has a fever for 4 days, especially if they have any other symptoms of Kawasaki disease.

Sometimes Kawasaki disease can affect the walls of the coronary arteries. These arteries bring blood and oxygen to your heart. This can lead to:

• An aneurysm (bulging and thinning of the walls of the arteries). This can raise the risk of blood clots in the arteries. If the blood clots are not treated, they could lead to a heart attack or internal bleeding.
• Inflammation in the heart.
• Heart valve problems.

Kawasaki disease can also affect other parts of the body, including the brain and nervous system, the immune system, and the digestive system.

There is no specific test for Kawasaki disease. To find out if your child has Kawasaki disease, your child's provider:

• Will do a physical exam, which includes looking at the signs and symptoms
• Will likely order blood and urine tests to rule out other diseases and check for signs of inflammation
• May order tests to check for damage to the heart, such as an echocardiogram and electrocardiogram (EKG)

Kawasaki disease is usually treated in the hospital with an intravenous (IV) dose of immunoglobulin (IVIG) antibodies. Antibodies are proteins that your immune system makes to fight infections.

Aspirin may also be part of the treatment. But do not give your child aspirin unless the health care provider tells you to. Aspirin can cause Reye syndrome in children. This is a rare, serious illness that can affect the brain and liver.

Treatment usually works. But if it is not working well enough, the provider may also give your child other medicines to fight the inflammation. If the disease affects your child's heart, they might need additional medicines, surgery, or other medical procedures.

Your liver is the largest organ inside your body. It helps your body digest food, store energy, and remove poisons.

There are many kinds of liver diseases:

• Diseases caused by viruses, such as hepatitis A, hepatitis B, and hepatitis C
• Diseases caused by drugs, poisons, or too much alcohol. Examples include fatty liver disease and cirrhosis.
• Liver cancer
• Inherited diseases, such as hemochromatosis and Wilson disease

Symptoms of liver disease can vary, but they often include swelling of the abdomen and legs, bruising easily, changes in the color of your stool and urine, and jaundice, or yellowing of the skin and eyes. Sometimes there are no symptoms. Tests such as imaging tests and liver function tests can check for liver damage and help to diagnose liver diseases.