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Your immune system protects you from disease and infection by attacking germs that get into your body, such as viruses and bacteria. Your immune system can tell that the germs aren't part of you, so it destroys them. If you have an autoimmune disease, your immune system attacks the healthy cells of your organs and tissues by mistake.

There are more than 80 types of autoimmune diseases. They can affect almost any part of your body. For example, alopecia areata is an autoimmune disease of the skin that causes hair loss. Autoimmune hepatitis affects the liver. In type 1 diabetes, the immune system attacks the pancreas. And in rheumatoid arthritis, the immune system can attack many parts of the body, including the joints, lungs, and eyes.

No one is sure why autoimmune diseases happen. But you can't catch them from other people.

Autoimmune diseases do tend to run in families, which means that certain genes may make some people more likely to develop a problem. Viruses, certain chemicals, and other things in the environment may trigger an autoimmune disease if you already have the genes for it.

Millions of Americans of all ages have autoimmune diseases. Women develop many types of autoimmune diseases much more often than men. And if you have one autoimmune disease, you are more likely to get another.

The symptoms of an autoimmune disease depend on the part of your body that's affected. Many types of autoimmune diseases cause redness, swelling, heat, and pain, which are the signs and symptoms of inflammation. But other illnesses can cause the same symptoms.

The symptoms of autoimmune diseases can come and go. During a flare-up, your symptoms may get severe for a while. Later on, you may have a remission, which means that your symptoms get better or disappear for a period of time.

Doctors often have a hard time diagnosing autoimmune diseases. There's usually not a specific test to show whether you have a certain autoimmune disease. And the symptoms can be confusing. That's because many autoimmune diseases have similar symptoms. And some symptoms, such as muscle aches, are common in many other illnesses. So it can take a long time and some visits to different types of doctors to get a diagnosis.

To help your doctor find out if an autoimmune disease is causing your symptoms,:

• Learn about the health conditions in your family history. What health problems did your grandparents, aunts, uncles, and cousins have? Write down what you learn and share it with your doctor.
• Keep track of your symptoms, including how long they last and what makes them better or worse. Share your notes with your doctor.
• See a specialist who deals with the symptoms that bother you most. For example, if you have rash, see a dermatologist (skin doctor).

The treatment depends on the disease. In most cases, the goal of treatment is to suppress (slow down) your immune system, and ease swelling, redness, and pain from inflammation. Your doctor may give you corticosteroids or other medicines to help you feel better. For some diseases, you may need treatment for the rest of your life.

Eosinophils are a type of white blood cell. They help fight off infections and play a role in your body's immune response. They can also build up and cause inflammation.

Normally your blood doesn't have a large number of eosinophils. Your body may produce more of them in response to:

• Allergic disorders
• Skin conditions
• Parasitic and fungal infections
• Autoimmune diseases
• Some cancers
• Bone marrow disorders

In some conditions, the eosinophils can move outside the bloodstream and build up in organs and tissues. This can happen in many different parts of the body, including the esophagus, heart, lungs, blood, and intestines. Treatment of eosinophilic disorders can vary, depending on the cause and which part of the body is affected. Steroids are often part of the treatment.

Hepatitis is inflammation of the liver. Inflammation is swelling that happens when tissues of the body are injured or infected. It can damage your liver. This swelling and damage can affect how well your liver functions.

Hepatitis can be an acute (short-term) infection or a chronic (long-term) infection. Some types of hepatitis cause only acute infections. Other types can cause both acute and chronic infections.

There are different types of hepatitis, with different causes:

• Viral hepatitis is the most common type. It is caused by one of several viruses -- hepatitis viruses A, B, C, D, and E. In the United States, A, B, and C are the most common.
• Alcoholic hepatitis is caused by heavy alcohol use
• Toxic hepatitis can be caused by certain poisons, chemicals, medicines, or supplements
• Autoimmune hepatitis is a chronic type in which your body's immune system attacks your liver. The cause is not known, but genetics and your environment may play a role.

Hepatitis A and hepatitis E usually spread through contact with food or water that was contaminated with an infected person's stool. You can also get hepatitis E by eating undercooked pork, deer, or shellfish.

Hepatitis B, hepatitis C, and hepatitis D spread through contact with the blood of someone who has the disease. Hepatitis B and D may also spread through contact with other body fluids. This can happen in many ways, such as sharing drug needles or having unprotected sex.

The risks are different for the different types of hepatitis. For example, with most of the viral types, your risk is higher if you have unprotected sex. People who drink a lot over long periods of time are at risk for alcoholic hepatitis.

Some people with hepatitis do not have symptoms and do not know they are infected. If you do have symptoms, they may include:

• Fever
• Fatigue
• Loss of appetite
• Nausea and/or vomiting
• Abdominal pain
• Dark urine
• Clay-colored bowel movements
• Joint pain
• Jaundice, yellowing of your skin and eyes

If you have an acute infection, your symptoms can start anywhere between 2 weeks to 6 months after you got infected. If you have a chronic infection, you may not have symptoms until many years later.

Chronic hepatitis can lead to complications such as cirrhosis (scarring of the liver), liver failure, and liver cancer. Early diagnosis and treatment of chronic hepatitis may prevent these complications.

To diagnose hepatitis, your health care provider:

• Will ask about your symptoms and medical history
• Will do a physical exam
• Will likely do blood tests, including tests for viral hepatitis
• Might do imaging tests, such as an ultrasound, CT scan, or MRI
• May need to do a liver biopsy to get a clear diagnosis and check for liver damage

Treatment for hepatitis depends on which type you have and whether it is acute or chronic. Acute viral hepatitis often goes away on its own. To feel better, you may just need to rest and get enough fluids. But in some cases, it may be more serious. You might even need treatment in a hospital.

There are different medicines to treat the different chronic types of hepatitis. Possible other treatments may include surgery and other medical procedures. People who have alcoholic hepatitis need to stop drinking. If your chronic hepatitis leads to liver failure or liver cancer, you may need a liver transplant.

There are different ways to prevent or lower your risk for hepatitis, depending on the type of hepatitis. For example, not drinking too much alcohol can prevent alcoholic hepatitis. There are vaccines to prevent hepatitis A and B. Autoimmune hepatitis cannot be prevented.

NIH: National Institute of Diabetes and Digestive and Kidney Diseases

Lupus is a chronic (long-lasting) type of autoimmune disease.Autoimmune diseases happen when your immune system attacks healthy cells and tissues by mistake. This attack causes inflammation. It can also damage many parts of the body, including the joints, skin, kidneys, heart, lungs, and brain.

There are several types of lupus:

• Systemic lupus erythematosus (SLE) is the most common type. It can be mild or severe and can affect many parts of the body.
• Cutaneous lupus affects the skin. It causes a rash or sores, usually after your skin is exposed to sunlight. The two major types of cutaneous lupus are discoid lupus and subacute cutaneous lupus.
• Drug-induced lupus is caused by a reaction to some medicines. The symptoms may start 3 to 6 months after starting the medicine. The symptoms usually go away when you stop taking the medicine.
• Neonatal lupus, which is rare, affects newborns. It is caused by certain antibodies that are passed from the pregnant parent to the baby.

The cause of lupus is unknown. Researchers are studying what might cause or trigger the disease, such as:

• Genetics
• Environmental factors, such as viral infections, sunlight, certain medicines, and smoking
• Problems with the immune system

Anyone can get lupus, but women get it much more often than men.

Lupus is more common in African Americans than in White people. It is also more common in people of American Indian and Asian descent. African American and Hispanic women are more likely to have severe forms of lupus.

Lupus can have many symptoms, and they differ from person to person. Some of the more common ones are:

• Arthritis, causing painful and swollen joints and morning stiffness
• Fever
• Fatigue or feeling tired often
• Red rashes, most often on the face (also called the "butterfly rash")
• Chest pain when taking a deep breath
• Hair loss
• Pale or purple fingers or toes, from cold and stress (Raynaud phenomenon)
• Sensitivity to the sun
• Swelling in legs or around eyes
• Mouth ulcers
• Swollen glands
• Headache and dizziness
• Confusion and memory problems

Symptoms may come and go. When you are having symptoms, it is called a flare. Flares can range from mild to severe. New symptoms may appear at any time.

Lupus causes inflammation throughout your body. This can cause problems in your organs, including:

• Kidney damage (lupus nephritis).
• Heart problems, including inflammation in the heart (myocarditis), heart valves, or lining of the heart muscle (pericarditis).
• Inflammation of blood vessels (vasculitis).
• Blood clots
• Inflammation of the tissue that surrounds the lungs (pleurisy). This can make it painful to breathe.

Some people with lupus may be more likely to develop other conditions, such as coronary artery disease (CAD) and atherosclerosis.

There is no specific test for lupus, and it's often mistaken for other diseases that cause similar symptoms. So it may take a while to get a diagnosis. To find out if you have lupus, your health care provider:

• Will ask about your symptoms, medical history, and family health history
• Will do a complete physical exam
• May order blood tests, such as ANA (antinuclear antibody), antibodies, complete blood count, and complement tests
• May order other tests, such as urine tests
• May do biopsies:
  • Skin biopsy (looking at skin samples under a microscope)
  • Kidney biopsy (looking at tissue from your kidney under a microscope)

There is no cure for lupus, but medicines and lifestyle changes can help control it.

People with lupus often need to see different providers. You will most likely have a primary care provider and a rheumatologist (a doctor who specializes in diseases of the joints and muscles). Which other specialists you will depend on how lupus affects your body. For example, if lupus is damaging your heart or blood vessels, you would see a cardiologist (a doctor who specializes in heart diseases).

Your primary care provider should coordinate care between all of your other providers and treat other problems as they come up. You and your primary care provider will develop a treatment plan to fit your needs. You will both review the plan often to make sure that it is working. You should report new symptoms to your provider right away so that your treatment plan can be changed, if needed.

The goals of a treatment plan are to:

• Prevent flares
• Treat flares when they occur
• Reduce organ damage and other problems
• Improve your quality of life

Treatments may include drugs to:

• Reduce fever, swelling, and pain
• Reduce inflammation in your body
• Prevent or reduce flares
• Reduce or prevent damage to joints
• Suppress (lower) the activity of your immune system

Besides taking medicines for lupus, you may need to take medicines for problems that are related to lupus such as high cholesterol, high blood pressure, or infection.

Alternative and complementary therapies are therapies that are not part of standard treatments. Some people try alternative and complementary therapies to improve their lupus symptoms. But research has not clearly shown whether these treatments may help or treat lupus. Talk to your provider before trying any new treatments.

It is important to take an active role in your treatment. It helps to learn more about lupus - being able to spot the warning signs of a flare can help you prevent the flare or make the symptoms less severe.

It is also important to find ways to cope with the stress of having lupus. Exercising and finding ways to relax may make it easier for you to cope. A good support system can also help.

NIH: National Institute of Arthritis and Musculoskeletal and Skin Diseases

Rheumatoid arthritis (RA) is a form of arthritis that causes pain, swelling, stiffness and loss of function in your joints. It can affect any joint but is common in the wrist and fingers.

More women than men get rheumatoid arthritis. It often starts in middle age and is most common in older people. You might have the disease for only a short time, or symptoms might come and go. The severe form can last a lifetime.

Rheumatoid arthritis is different from osteoarthritis, the common arthritis that often comes with older age. RA can affect body parts besides joints, such as your eyes, mouth and lungs. RA is an autoimmune disease, which means the arthritis results from your immune system attacking your body's own tissues.

No one knows what causes rheumatoid arthritis. Genes, environment, and hormones might contribute. Treatments include medicine, lifestyle changes, and surgery. These can slow or stop joint damage and reduce pain and swelling.

NIH: National Institute of Arthritis and Musculoskeletal and Skin Diseases

Sjogren's syndrome, also called Sjogren's disease, is a chronic (long-lasting) autoimmune disease. When you have an autoimmune disease, your immune system attacks healthy tissues and organs by mistake. In Sjogren's syndrome, your immune system attacks the glands that make moisture in the eyes, mouth, and other parts of the body. This causes a dry mouth and dry eyes. You may have dryness in other places that need moisture, such as your nose, throat, and skin. Sjogren's can also affect other parts of the body, including your joints, lungs, kidneys, blood vessels, digestive organs, and nerves.

Normally, your immune system protects the body from infection and disease. But with Sjogren's syndrome and other autoimmune diseases, your immune system attacks healthy tissues and organs. Researchers don't know for sure what causes the immune system to do this. But they think that it is caused by a combination of genetic and environmental factors. Studies have linked Sjogren's syndrome to gene changes in several genes. Some researchers also think that the disease may be triggered by something in the environment. For example, they think that one possible trigger could be a previous infection with a virus or bacteria.

Most people with Sjogren's syndrome are women. You can get it at any age, but it is most common in people in their 40s and 50s.

Sjogren's syndrome is more common in people who have other autoimmune diseases such as rheumatoid arthritis and lupus. This is known as a secondary form of Sjogren's syndrome. People who don't have another autoimmune disease have a primary form of Sjogren's syndrome.

Sjogren's syndrome may have different effects on the body. Not everyone will have the same symptoms. Some people have cycles of mild and then severe symptoms.

The two main symptoms are:

• Dry eyes. Your eyes may burn or itch or feel like they have sand in them. Sometimes your vision may be blurry, or you could be bothered by bright lights.
• Dry mouth. Your tongue and your throat may feel dry. You might have trouble swallowing, speaking, and tasting.

Sjogren's syndrome can also affect other parts of the body, causing symptoms such as:

• Joint and muscle pain
• Dry skin
• Rashes on the skin of hands or feet
• Numbness or tingling in the hands or feet
• Vaginal dryness
• Dry cough that doesn't go away
• Fatigue that doesn't go away

There is no single test for Sjogren's syndrome. To find out if you have it, your provider:

• Will ask about your medical history and symptoms.
• Will do a physical exam, which includes checking for signs of dry mouth and signs of related autoimmune diseases.
• May order tests, including:
  • Eye tests to see if you produce a normal amount of tears and to find out if your eyes have been damaged by dryness.
  • Salivary gland tests to measure how much saliva your mouth produces. They could include imaging tests and a biopsy.
  • Blood tests.

There is no cure for Sjogren's syndrome. Treatment focuses on relieving your symptoms. The treatments can be different for each person, depending on which parts of the body are affected. They may include:

• Eye drops (artificial tears) or ointments to relieve dryness in the eyes.
• Saliva substitutes.
• Prescription medicines that cause your salivary glands to make more saliva.
• A minor procedure that places small plugs the tear duct in the corners of the eyes. The plugs block your tears from draining so they stay in your eyes longer.
• Medicines to help with other symptoms caused by Sjogren's syndrome, such as medicines for pain and inflammation.
• Medicines that suppress (weaken) your immune system (for severe cases).

You can also try to relieve some of your symptoms by sucking on sugar-free candy, drinking water often, increasing the humidity in your room, and not smoking. Because having a dry mouth can raise your risk of cavities, it's important to take good care of your teeth and see your dentist regularly.

Your thyroid is a small, butterfly-shaped gland in the front of your neck. It makes hormones that control the way the body uses energy. These hormones affect nearly every organ in your body and control many of your body's most important functions. For example, they affect your breathing, heart rate, weight, digestion, and moods.

Thyroid diseases cause your thyroid to make either too much or too little of the hormones. Some of the different thyroid diseases include:

• Goiter, an enlargement of the thyroid gland
• Hyperthyroidism, which happens when your thyroid gland makes more thyroid hormones than your body needs
• Hypothyroidism, which happens when your thyroid gland does not make enough thyroid hormones
• Thyroid cancer
• Thyroid nodules, lumps in the thyroid gland
• Thyroiditis, swelling of the thyroid

To diagnose thyroid diseases, your health care provider may use a medical history, physical exam, and thyroid tests. In some cases, your provider may also do a biopsy.

Treatment depends on the problem, how severe it is, and what your symptoms are. Possible treatments may include medicines, radioiodine therapy, or thyroid surgery.

Dept. of Health and Human Services Office on Women's Health

Your thyroid is a small, butterfly-shaped gland in the front of your neck. It makes hormones that control the way the body uses energy. These hormones affect nearly every organ in your body and control many of your body's most important functions. For example, they affect your breathing, heart rate, weight, digestion, and moods.

Thyroid tests check how well your thyroid is working. They are also used to diagnose and help find the cause of thyroid diseases such as hyperthyroidism and hypothyroidism. Thyroid tests include blood tests and imaging tests.

Blood tests for your thyroid include:

• TSH. It measures thyroid-stimulating hormone. This is usually the first test your healthcare provider will order.
• T3 and T4.They measure the level of the different thyroid hormones in your blood.
• Thyroid antibodies test. It measures certain thyroid antibodies (markers in the blood). This test may help diagnose autoimmune thyroid disorders.

Imaging tests include:

• CT scans
• Ultrasound
• Nuclear medicine tests, including:
  • Thyroid scan. It uses small amounts of radioactive material to create a picture of the thyroid, showing its size, shape, and position. It can help find the cause of hyperthyroidism and check for thyroid nodules (lumps in the thyroid).
  • Radioactive iodine uptake test, or thyroid uptake test. It checks how well your thyroid is working and can help find the cause of hyperthyroidism.

NIH: National Institute of Diabetes and Digestive and Kidney Diseases