guillain

Guillain-Barre syndrome is a rare disorder that causes your immune system to attack your peripheral nervous system (PNS). The PNS nerves connect your brain and spinal cord with the rest of your body. Damage to these nerves makes it hard for them to transmit signals. As a result, your muscles have trouble responding to your brain. No one knows what causes the syndrome. Sometimes it is triggered by an infection, surgery, or a vaccination.

The first symptom is usually weakness or a tingling feeling in your legs. The feeling can spread to your upper body. In severe cases, you become almost paralyzed. This is life-threatening. You might need a respirator to breathe. Symptoms usually worsen over a period of weeks and then stabilize.

Guillain-Barre can be hard to diagnose. Possible tests include nerve tests and a spinal tap. Most people recover. Recovery can take a few weeks to a few years. Treatment can help symptoms, and may include medicines or a procedure called plasma exchange.

NIH: National Institute of Neurological Disorders and Stroke

The flu (influenza) is a respiratory infection. It is caused by influenza viruses that infect your nose, throat, and lungs. These viruses can spread from person to person.

Most people with the flu get better on their own, without medical care. But for some people, the flu is serious. It can cause complications and sometimes even death. People who are 65 and older, under age 5, pregnant, or have certain health conditions are at higher risk of flu complications.

Getting vaccinated against the flu each year is best way to lower your risk of the flu and its complications.

There are many reasons to get a flu shot each year:

• It may keep you from getting sick with the flu.
• If you do get the flu, it may be less severe. You may also be less likely to have complications or need to be hospitalized with the flu.
• If you have certain chronic health conditions, getting a flu shot may help prevent the flu from making your condition worse. For example, if you have COPD or diabetes, the flu can worsen your condition so much that you might need to be hospitalized. Getting a flu shot can lower this risk.
• Getting the vaccine during pregnancy not only helps protect you from the flu during and after pregnancy. It also helps protect your baby from flu during their first few months of life.
• It has been shown to lower the risk of severe life-threatening flu in children.
• It may also protect the people around you, including those who are at higher risk of complications.

The flu vaccine causes your immune system to make antibodies about two weeks after you get the shot. These antibodies provide protection against infection with the flu viruses that are in the vaccine.

The U.S Centers for Disease Control and Prevention (CDC) recommends annual flu shots for everyone 6 months and older, with a few rare exceptions.

Flu shots are especially important for people who are at high risk of developing serious complications from the flu.

There are different types of flu vaccines. There are injectable vaccines (shots) and nasal spray vaccines. There are also some vaccines especially for people 65 and older. Ask your health care provider which one is right for you.

There are some people who should not get a flu shot:

• Children younger than 6 months of age.
• Have severe, life-threatening allergies to flu vaccine or any ingredient in the vaccine. This might include gelatin, antibiotics, or other ingredients.

Some people need to talk to their provider before they get a flu shot. They include people who:

• Have an allergy to any of the ingredients in the vaccine.
• Have ever had Guillain-Barre syndrome(GBS). Some people with a history of GBS should not get a flu vaccine.

If you are moderately or severely ill, you usually need to wait until you recover before getting a flu shot.

You need to get a flu shot every year because:

• Your immune protection from the vaccine declines over time. You need to get the shot every year to boost that protection.
• Flu viruses are constantly changing, so every year, the flu vaccine is updated. The flu vaccine will include protection against the viruses that will most likely be common during the upcoming flu season.

For most people who need only one dose of the flu vaccine for the season, September and October are usually good times to get it. It's best to be vaccinated by the end of October.

Some children need two doses of the flu vaccine. They should get their first dose as soon as the vaccine is available. They need to get the second dose at least four weeks after the first.

If you are pregnant, talk to your provider about when to get the vaccine. When you should get it can vary, based on how far along you are in your pregnancy.

Flu vaccines have been shown to be safe. But like any medical product, they can cause side effects. If you have any side effects, they are usually mild and go away on their own within a few days. Common side effects include:

• Soreness, redness, and/or swelling from the shot
• Headache
• Fever
• Nausea
• Muscle aches

The flu shot, like other injections, can occasionally cause fainting. In rare cases, some people have a serious allergic reaction.

Centers for Disease Control and Prevention

Acute flaccid myelitis (AFM) is a neurologic disease. It is rare, but serious. It affects an area of the spinal cord called gray matter. This can cause the muscles and reflexes in the body to become weak.

Because of these symptoms, some people call AFM a "polio-like" illness. But it is different from polio. AFM is not caused by polioviruses.

AFM can be caused by several different viruses. Researchers think that enteroviruses have been causing the recent increases in the number of children with AFM. AFM can also be caused by other viruses, including flaviviruses, herpesviruses, and adenoviruses.

Most people with AFM had a mild respiratory illness or fever (like you would get from a viral infection) before they got AFM.

Anyone can get AFM, but most cases (more than 90%) have been in young children.

Most people with AFM will suddenly have:

• Arm or leg weakness
• A loss of muscle tone and reflexes

Some people also have other symptoms, including:

• Facial drooping/weakness
• Trouble moving the eyes
• Drooping eyelids
• Trouble swallowing
• Slurred speech
• Pain in the arms, legs, back, or neck

Sometimes AFM can weaken the muscles that you need for breathing. This can lead to respiratory failure, which is very serious. If you get respiratory failure, you may need to use a ventilator (breathing machine) to help you breathe.

If you or your child develops any of these symptoms, get medical care right away.

AFM causes many of the same symptoms as other neurologic diseases, such as transverse myelitis and Guillain-Barre syndrome. This can make it difficult to diagnose. To find out if you have AFM, your doctor may use:

• A neurologic exam, including looking at where there is weakness, poor muscle tone, and decreased reflexes
• An MRI to look at the spinal cord and brain
• Lab tests on the cerebrospinal fluid (the fluid around the brain and spinal cord)
• Nerve conduction and electromyography (EMG) studies. These tests check nerve speed and the response of muscles to the messages from the nerves.

It is important that the tests are done as soon as possible after the symptoms start.

There is no specific treatment for AFM. A doctor who specializes in treating brain and spinal cord illnesses (neurologist) may recommend treatments for specific symptoms. For example, physical and/or occupational therapy may help with arm or leg weakness. Researchers do not know the long-term outcomes of people who get AFM.

There is no specific way to prevent AFM. But you can take steps to prevent getting sick from a virus by:

• Washing your hands often with soap and water
• Avoiding touching your face with unwashed hands
• Avoiding close contact with people who are sick
• Cleaning and disinfecting surfaces that you frequently touch, including toys
• Covering coughs and sneezes with a tissue or upper shirt sleeve, not hands
• Staying home when sick

Centers for Disease Control and Prevention

Campylobacter infection is a common foodborne illness. You usually get it from eating contaminated food, especially raw or undercooked poultry. You can also get it from drinking contaminated water or raw milk, or handling infected animal feces (poop).

Some infected people don't have any symptoms. If you do have symptoms, they start two to five days after you are infected. They usually last about one week, and can include:

• Diarrhea (which could be bloody)
• Cramping
• Abdominal pain
• Fever
• Fatigue
• Nausea and vomiting

Health care providers use stool tests to make a diagnosis. Most people get better without treatment. You should drink extra fluids for as long as the diarrhea lasts. People who have a severe infection or a weakened immune system may need to take antibiotics. In rare cases, the infection can cause reactive arthritis or Guillain-Barre syndrome.

To prevent Campylobacter infection, cook poultry thoroughly. Use a separate cutting board and utensils for meats. Make sure to clean them carefully with soap and hot water after you use them.

Centers for Disease Control and Prevention

Paralysis is the loss of muscle function in part of your body. It happens when something goes wrong with the way messages pass between your brain and muscles. Paralysis can be complete or partial. It can occur on one or both sides of your body. It can also occur in just one area, or it can be widespread. Paralysis of the lower half of your body, including both legs, is called paraplegia. Paralysis of the arms and legs is quadriplegia.

Most paralysis is due to strokes or injuries such as spinal cord injury or a broken neck. Other causes of paralysis include:

• Nerve diseases such as amyotrophic lateral sclerosis
• Autoimmune diseases such as Guillain-Barre syndrome
• Bell's palsy, which affects muscles in the face

Polio used to be a cause of paralysis, but polio no longer occurs in the U.S.

Tetanus, diphtheria, and pertussis (whooping cough) are serious bacterial infections:

• Tetanus is an uncommon disease that requires immediate treatment in a hospital. It causes painful tightening of the muscles, usually all over the body. It can lead to "locking" of the jaw.
• Diphtheria usually affects the nose and throat. But it can also affect the skin and other body parts.
• Whooping cough can cause uncontrollable coughing fits. It may begin like a cold, but unlike a cold, the coughing can last for weeks or months.

Vaccines can protect you from these diseases. In the U.S., there are three combination vaccines:

• DTaP (diphtheria, tetanus, and pertussis) prevents all three diseases. It is for babies and children under age 7. There are several different DTaP vaccines. Some of them also protect against other diseases.
• Tdap (tetanus, diphtheria, and pertussis) also prevents all three diseases. It is for older children and adults.
• Td (tetanus and diphtheria) prevents those two diseases. It is for older children and adults. It is usually given as a booster dose every 10 years. You may also get it after 5 years if you get a severe or dirty wound or burn.

Some people should not get these vaccines, including those who have had severe reactions to the shots before. Check with your health care provider first if you have seizures, a neurologic problem, or Guillain-Barre syndrome.

People with minor illnesses such as a cold can get vaccinated. But those who are more ill may need wait until they feel better before getting some vaccines.

Centers for Disease Control and Prevention

Your immune system protects you from disease and infection by attacking germs that get into your body, such as viruses and bacteria. Your immune system can tell that the germs aren't part of you, so it destroys them. If you have an autoimmune disease, your immune system attacks the healthy cells of your organs and tissues by mistake.

There are more than 80 types of autoimmune diseases. They can affect almost any part of your body. For example, alopecia areata is an autoimmune disease of the skin that causes hair loss. Autoimmune hepatitis affects the liver. In type 1 diabetes, the immune system attacks the pancreas. And in rheumatoid arthritis, the immune system can attack many parts of the body, including the joints, lungs, and eyes.

No one is sure why autoimmune diseases happen. But you can't catch them from other people.

Autoimmune diseases do tend to run in families, which means that certain genes may make some people more likely to develop a problem. Viruses, certain chemicals, and other things in the environment may trigger an autoimmune disease if you already have the genes for it.

Millions of Americans of all ages have autoimmune diseases. Women develop many types of autoimmune diseases much more often than men. And if you have one autoimmune disease, you are more likely to get another.

The symptoms of an autoimmune disease depend on the part of your body that's affected. Many types of autoimmune diseases cause redness, swelling, heat, and pain, which are the signs and symptoms of inflammation. But other illnesses can cause the same symptoms.

The symptoms of autoimmune diseases can come and go. During a flare-up, your symptoms may get severe for a while. Later on, you may have a remission, which means that your symptoms get better or disappear for a period of time.

Doctors often have a hard time diagnosing autoimmune diseases. There's usually not a specific test to show whether you have a certain autoimmune disease. And the symptoms can be confusing. That's because many autoimmune diseases have similar symptoms. And some symptoms, such as muscle aches, are common in many other illnesses. So it can take a long time and some visits to different types of doctors to get a diagnosis.

To help your doctor find out if an autoimmune disease is causing your symptoms,:

• Learn about the health conditions in your family history. What health problems did your grandparents, aunts, uncles, and cousins have? Write down what you learn and share it with your doctor.
• Keep track of your symptoms, including how long they last and what makes them better or worse. Share your notes with your doctor.
• See a specialist who deals with the symptoms that bother you most. For example, if you have rash, see a dermatologist (skin doctor).

The treatment depends on the disease. In most cases, the goal of treatment is to suppress (slow down) your immune system, and ease swelling, redness, and pain from inflammation. Your doctor may give you corticosteroids or other medicines to help you feel better. For some diseases, you may need treatment for the rest of your life.

Nerves are like wires that carry messages back and forth between your brain and your body. Your peripheral nerves branch off from your brain and spinal cord and connect to all parts of your body, including your muscles and organs. Peripheral nerves carry messages from your brain that control your movement, breathing, heartbeat, digestion, and more. They also carry messages from your body to your brain, so you can feel things, such as pain, heat, and cold.

Peripheral nerve disorders happen when one or more peripheral nerves are damaged. Damaged nerves may not carry messages correctly, or they may not work at all. As a result, you may have pain, trouble walking, or a variety of other problems, depending on which nerves are involved.

Peripheral nerve disorders are very common. There are more than 100 different types.

Many things can damage nerves and lead to peripheral nerve disorders:

• Diabetes is the most common cause of peripheral nerve disorders. Most people with diabetes will develop diabetic nerve problems.
• Physical injury (trauma) that stretches, crushes, squeezes, cuts, or puts pressure on one or more nerves. Some examples of peripheral nerve disorders from physical injury include complex regional pain syndrome and brachial plexus injuries.
• Health conditions, including:
  • Certain cancers and their treatment (chemotherapy and radiation therapy).
  • Infections, such as HIV and Lyme disease.
  • Problems with blood or blood vessels.
  • Autoimmune diseases, such as rheumatoid arthritis and lupus.
  • Kidney or liver disease.
• Certain medicines.
• Contact with certain toxic substances, such as lead or mercury.
• Alcohol use disorder (AUD) and smoking.
• Vitamin imbalances, especially a lack of vitamin B12.
• Your genes, including changes in your genes or conditions that you inherit from your parents, such as Charcot-Marie-Tooth disease.

In certain cases, the cause of peripheral nerve disorder is not known.

The symptoms of peripheral nerve disorders depend on which nerves are affected, what is causing the damage, and how serious it is:

• Weak or aching muscles
• Problems with balance, walking, or using your arms and hands
• Cramps or twitching muscles
• Muscle shrinking

• Tingling, numbness, or pain often in the hands and feet
• Not being able to feel heat, cold, or pain, such as a cut on your foot
• Pain from even light touch

• A heartbeat that's too fast or too slow
• Trouble swallowing
• Sweating too much or too little
• Vomiting, diarrhea, or constipation
• Problems with urination or sexual function

Symptoms may range from mild to very strong. They may develop quickly over days or slowly over months and years. But they are rarely life-threatening.

To find out if you have a peripheral nerve disorder, your provider will:

• Ask about your medical history
• Ask about your family health history
• Do a physical exam
• Order tests, which may include:
  • Blood tests
  • Genetic tests
  • Nerve tests that measure:
    • Electrical activity in your nerves and muscles
    • How well your autonomic nerves are working
  • A biopsy of nerve or skin tissue
  • CT or MRI scan to see what may be pressing on your nerves

It's important to treat any conditions that are causing nerve damage. In certain cases, that will allow your nerves to heal over time.

Treatment for symptoms depends on the type of peripheral nerve disorder you have, where it is, and how severe. Treatment options include:

• Braces or splints
• Over-the-counter patches and skin creams
• Prescription medicines
• Non-drug pain management, such as electrical stimulation or relaxation therapy
• Surgery to relieve pressure on a nerve

You can help prevent peripheral nerve disorders by:

• Managing health conditions that may cause nerve damage, especially diabetes
• Preventing falls and accidents
• Avoiding toxic substances
• Being careful to avoid repeated motions and body positions that press on your nerves
• Eating a balanced diet, exercising, limiting alcohol, and not smoking

NIH: National Institute of Neurological Disorders and Stroke